Dalla Lana School of Public Health

Faculty Member

Jeremy Alexander Scott Ph.D.

Education & Training History

Postdoctoral Fellowship

University of Toronto

Supervisors: Drs. Philip A. Marsden and Jeffrey M. Drazen (Harvard University)

Research: Contribution of alternative transcription of neuronal nitric oxide synthase to the pathogenesis of asthma.

Ph.D. Pharmacology & Toxicology

University of Western Ontario

Supervisors: Drs. David G. McCormack & John R. Bend

Thesis: Alterations of nitric oxide synthase isozymes in sepsis.

M.Sc. Pharmacology

University of Western Ontario

Supervisors: Drs. David G. McCormack & Michael A. Cook

Thesis: Nonadrenergic noncholinergic control of the human and guinea pig pulmonary arteries.

B.Sc. Honours Pharmacology & Toxicology

University of Western Ontario

Other Affiliations

Southern Ontario Centre for Atmospheric Aerosol Research (SOCAAR)

Canadian Healthy Infant Longitudinal Development (CHILD)

Centre for Research Expertise in Occupational Disease

Primary Teaching Responsibilities

CHL5912H Industrial Toxicology (Course Coordinator). Dalla Lana School of Public Health, University of Toronto (Core Course).

Professional Summary & Appointments

2014-Present Associate Professor, Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON.

2005-Present Investigator, Canadian Aerosol Research Network/Southern Ontario Centre for Atmospheric Aerosol Research.

2005-Present Researcher, Allergies Genes and the Environment, Network of Centres of Excellence (AllerGen NCE).

2005-Present Investigator, Centre for Research Expertise in Occupational Disease (CREOD).

Honours & Awards

Canadian Institutes for Health Research (CIHR) Post-Doctoral Fellowship.

CIHR/Canadian Lung Association/ Merck-Frosst Post-Doctoral Fellowship.

Harry and Gudrun Sharma Award – Recognizes excellence in research and academic performance by a graduate student in the Department of Pharmacology and Toxicology, University of Western Ontario.

Representative Publications

Last 5 years. Trainees are underlined. Bold indicates individual role or as part of the Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators.

2017

1. Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL, Canadian Healthy Infant Longitudinal Development (CHILD) Study Investigators. Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. Microbiome 2017; 5: 40. PMID: 28381231 (CHILD)
2. Tran MM, Lefebvre DL, Dai D, Dharma C, Subbarao P, Lou W, Azad MB, Becker AB, Mandhane PJ, Turvey SE, Sears MR, CHILD Study Investigators. Timing of food introduction and development of food sensitization in a prospective birth cohort. Pediatr Allergy Immunol 2017. PMID: 28557044 (CHILD)
3. Salehi S, Wang X, Juvet S, Scott JA^*, Chow CW^*. Syk regulates neutrophilic airway hyperresponsiveness in a chronic mouse model of allergic airways inflammation. PLoS ONE 12(1): e0163614. doi:10.1371/journal. pone.0163614. ^*Senior authors contributed equally to this work. (Co-SRA)
4. Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, HayGlass KT. In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory? PLoS One 2017; 12: e0177813. PMID: 28636613 (CHILD)
5. Bridgman SL, Azad MB, Field CJ, Haqq AM, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR, Scott JA, Wishart DS, Kozyrskyj AL, CHILD Study Investigators. Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations. Front Nutr 2017; 4: 11. PMID: 28443284 (CHILD)
6. Azad MB, Vehling L, Lu Z, Dai D, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, and CHILD Study Investigators. Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study. European Respiratory J 2017; 49. PMID: 28461293 (CHILD)

 

2016

7. Stiemsma LT, Arrieta MC, Dimitriu PA, Cheng J, Thorson L, Lefebvre DL, Azad MB, Subbarao P, Mandhane P, Becker A, Sears MR, Kollmann TR; CHILD Study Investigators Study Investigators, Mohn WW, Finlay BB, Turvey SE. Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma. Clin Sci (Lond). 2016 Dec 1;130(23):2199-2207. PMID: 27634868 (CHILD)
8. Bridgman SL, Konya T, Azad MB, Guttman DS, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P; CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL. High fecal IgA is associated with reduced Clostridium difficile colonization in infants. Microbes Infect. 2016 Sep;18(9):543-9. doi: 10.1016/j.micinf.2016.05.001. PMID: 27235197 (CHILD)
9. Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, Lefebvre D, Alexander RT, Dickson CT, Li L, Becker AB, Subbarao P, Turvey SE, Pei J, Sears MR, Mandhane PJ; CHILD Study Investigators. Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model. EBioMedicine. 2016 Jun;8:331-40. doi: 10.1016/j.ebiom.2016.04.025. Epub 2016 Apr 22. (CHILD)
10. Azad MB, Sharma AK, de Souza RJ, Dolinsky VW, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Lefebvre DL, Sears MR; Canadian Healthy Infant Longitudinal Development Study Investigators. Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index. JAMA Pediatr. 2016 Jul 1;170(7):662-70. doi: 10.1001/jamapediatrics.2016.0301. PMID: 27159792 (CHILD)
11. Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL. Infant gut immunity: a preliminary study of IgA associations with breastfeeding. J Dev Orig Health 2016 Feb;7(1):68-72. doi: 10.1017/S2040174415007862. PMID: 26690933 (CHILD)

 

2015

5. Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Brett Finlay B. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015 Sep 30;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271. PMID: 26424567 (CHILD)
6. Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study. BJOG. 2016 May;123(6):983-93. PMID: 26412384 (CHILD)
7. Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WY, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR; CHILD Study Investigators. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015 Oct;70(10):998-1000. PMID: 26069286 (CHILD)
8. Scott JA, North ML, Rafii M, Pencharz P, Grasemann H. Plasma arginine metabolites reflect airways dysfunction in a murine model of allergic airways inflammation. J Appl Physiol 2015 May 15;118(10):1229-33. Impact Factor: 4.193 PMID: 25979935 (PA)
9. Wang XM, Khanna N, Wu J, Godri Pollit K, Evans GJ, Chow CW^*, Scott JA^*. Syk mediates airway contractility independent of leukocyte function. Allergy. 2015;70:429-435. ^*Senior authors contributed equally to this work. Impact Factor: 5.995 PMID: 25556883 (Co-SRA)
10. Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P, Turvey SE, Wheeler AJ, Zeng L, Sears MR, Brook JR; CHILD Study Investigators. The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures. J Expo Sci Environ Epidemiol. 2015 Nov-Dec;25(6):580-92. doi: 10.1038/jes.2015.7. Epub 2015 Mar 25. PMID: 25805254 (CHILD)
11. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy. 2015 Mar;45(3):632-43. doi: 10.1111/cea.12487. PMID: 25599982 (CHILD)
12. Grasemann H, Dhaliwal R, Ivanovska J, Kantores C, McNamara P, Scott JA, Belik J, Jankov RP. Arginase inhibition prevents bleomycin-induced pulmonary hypertension, collagen deposition and vascular remodeling in neonatal rats. Am J Physiol Lung Cell Mol Physiol. 2015;308(6):L503-10. PMID: 25595650. Impact Factor: 4.721 PMID: 25595650 (CA)
13. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD; CHILD Study Investigators. The Canadian Healthy Infant Longitudinal Development birth cohort study: biological samples and biobanking. Paediatr Perinat Epidemiol. 2015 Jan;29(1):84-92. Impact Factor: 2.811 PMID: 25405552 (CHILD)

2014

14. Akhtar U, Rastogi N, McWhinney R, Urch B, Chow CW, Evans GJ^*, Scott JA^*. The combined effects of physicochemical properties of size-fractionated ambient particulate matter on in vitro toxicity in human A549 lung epithelial cells. Toxicology Reports. 2014;1:145-156. EDITORIAL Impact Factor: Pending (New Journal) (Co-SRA)
15. Scott JA, Grasemann H. Arginine metabolism in asthma. Immunol Allergy Clin North Am. 2014 Nov;34(4):767-775. INVITED REVIEW Impact Factor: 3.096 PMID: 25282289 (PA)
16. Hawkshaw C, Scott JA, Chow CW, Fish EN. LAPCs contribute to the pathogenesis of allergen-induced asthma. Allergy. 2014;69(7):924-35. Impact Factor: 5.883 PMID: 24836003 (CA)
17. Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA; CHILD Study Investigators. Associations between bacterial communities of house dust and infant gut. Environ Res. 2014 May;131:25-30. Impact Factor: 4.033 PMID: 24637181 (CHILD)
18. Scott JA, Duongh ML, Young AW, Subbarao P, Gauvreau GM, Grasemann H. Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD). J. Mol. Sci. 2014;15:6062-6071. Impact Factor: 3.257 PMID: 24727374 (PA)
19. Curley GF, Scott JA, Laffey JG. Therapeutic potential and mechanisms of action of mesenchymal stromal cells for acute respiratory distress syndrome. Curr Stem Cell Res Ther. 2014;9:319-29. Impact Factor: 2.963 PMID: 24588087 (CA)
20. Scott JA, Gauvreau GM, Grasemann H. Asymmetric dimethylarginine in asthma. European Respiratory Journal. 2014;43:647-648. Impact Factor: 6.355 PMID: 24488993 (PA)

 

2013

21. Scott JA, Grasemann H. ADMA – A Disease Marker for A Chest. 2013;144(2):367-8. EDITORIAL Impact Factor: 6.42 PMID: 23918098 (PA)
22. Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli A. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. J Am Heart Assoc. 2013;2(3):e000212. Impact Factor: Pending (New journal) PMID: 23782920 (CA)
23. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Sears MR, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol. 2013;9:15. Impact Factor: 3.0 PMID: 23607879 (CHILD)
24. North ML, Grasemann H, Khanna N, Inman MD, Gauvreau GM, Scott JA. Increased ornithine-derived polyamines cause airways hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2013;48:694-702. Impact Factor: 5.13 PMID: 23470627 (SRA)
25. Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013;185(5):385-94. doi: 10.1503/cmaj.121189. Impact Factor: 8.2 PMID: 23401405 (CHILD)
26. Castellanos Penten P, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA^*, Chow CW^*. Syk inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic murine model of asthma. J Allergy Clin Immunol. 2013;131:512-520. ^*Senior authors contributed equally to this work. Impact Factor: 12.047 PMID: 22981792 (Co-SRA)
27. Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL; CHILD Study Investigators. Gut microbiota diversity and atopic disease: does breast-feeding play a role? J Allergy Clin Immunol. 2013;131:247-8. Impact Factor: 12.047 PMID: 23199602 (CHILD)

 

2012

28. Arrandale VH, Kudla I, Kraut AG, Scott JA, Tarlo SM, Redlich C, Holness DL. Skin and respiratory symptoms among workers with suspected work-related disease. Occup Med (Lond) 2012;62:420-6. Impact Factor: 1.136 PMID: 22915563 (CA)
29. Rastogi N, McWhinney RD, Akhtar US, Urch B, Fila M, Abbatt JPD, Scott JA, Silverman FS, Brook JR, Evans GJ. Physical characterization of the University of Toronto coarse, fine, and ultrafine high-volume particle concentrator systems. Aerosol Sci Technol 2012;46:1015–1024. Impact Factor: 2.667 (CA)
30. Amatullah H, North ML, Akhtar US, Rastogi N, Urch B, Silverman F, Chow CW, Evans GJ, Scott JA. Comparative cardiopulmonary effects of size-fractionated airborne particulate matter. Inhal Toxicol 2012;24(3): 161–171. Impact Factor: 2.678 PMID: 22356274 (SRA)
31. Plant P, North ML, Ward A, Ward ME, Khanna N, Correa J, Scott JA^*, Batt J^*. Hypertrophic airway smooth muscle mass correlates with increased airflow resistance in chronic murine allergic asthma. Am J Respir Cell Mol Biol. 2012;46:532-540. ^*Senior authors contributed equally to this work. Impact Factor: 5.13 PMID: 22108300 (Co-SRA)
32. Wang X, Mychajlowycz M, Lau C, Gutierrez C, Scott JA, Chow CW. Syk mediates BEAS-2B cell migration and proliferation, and HRV-induced expression of VEGF and IL-8. J Pharmacol Exp Ther 2012;340:277-285. Impact Factor: 3.995 PMID: 22031919 (CA)